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Find out if D-mannose helps prevent urinary tract infections and how products compare.
Latest Update
D-Mannose for Preventing UTI?
Medically reviewed and edited by Tod Cooperman, M.D.
Updated April 11, 2024 ⓘ Published December 14, 2023
Summary
Does D-mannose help prevent urinary tract infections (UTIs)?
D-mannose, a naturally occurring sugar, is taken as a supplement in the hopes that it will prevent or treat UTIs. To-date, this benefit has only been suggested by results of preliminary studies but not in placebo-controlled clinical trials with only D-mannose, as needed to prove efficacy. A typical dose is 1 gram taken twice daily, but a 1.5-gram daily dose has also been used, as has a starting dose of 1 gram three times daily. (See What It Does. Also see our separate Cranberry Juices and Supplements Review)What did ConsumerLab find testing the quality of D-mannose supplements?
Testing of popular D-mannose supplements by ConsumerLab.com found none to be mislabeled with regard to the amount of D-mannose or contaminated with significant amounts of heavy metals. However, the suggested dosage on labels was, in most cases, inconsistent with clinical trials. In addition, although the D-mannose in products was essentially the same, the cost to obtain it ranged 1200%, indicating that D-mannose can be purchased for much lower cost from some products than others. (See What CL Found)
What is the best D-mannose supplement?
ConsumerLab chose one D-mannose powder as its overall Top Pick among tested D-mannose supplements based on high quality, low cost, and the ability to provide an appropriate dose of D-mannose. For those seeking the convenience of pills, ConsumerLab.com also selected a Top Pick D-mannose capsule.Does D-mannose have side effects?
D-mannose at standard dosing has been reported to be safe in trials lasting up to six months. Rarely, gastrointestinal side effects, such as diarrhea, have been reported. (See Concerns and Cautions)
+— 9 sources
In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:
Make sure you're choosing the best D-mannose supplements approved in our tests!
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D-mannose supplements compared in this review
Azo D-Mannose
BulkSupplements.com D-Mannose
GNC Herbal Plus Cranberry & D-Mannose
Microingredients D-Mannose Powder
NOW D-Mannose Pure Powder
NOW D-Mannose Urinary Support 500 mg
Nutricost D-Mannose
Pure Encapsulations D-Mannose
Solaray CranActin D-Mannose
Swanson D-Mannose
Uqora Urinary Care 1: Flush Proactive Regimen Part 1 - Pink Lemonade Flavor
You must be a member to get the full test results along with ConsumerLab.com's recommendations and quality ratings. You will get results for 10 D-mannose supplements selected for testing by ConsumerLab.com as well as for one other that passed the same testing in CL's voluntary Quality Certification Program. In this comprehensive review of D-mannose supplements you'll learn:
- Which D-mannose supplements passed testing, and which failed
- ConsumerLab's Top Picks among D-mannose supplements, including powders and capsules
- Which high-quality D-mannose supplements are also lowest cost
- What D-mannose can and cannot do for your health, including information about preventing and treating urinary tract infections (UTIs), and whether it can help with a rare condition (MPI-congenital disorder of glycosylation)
- What to look for on labels when choosing a D-mannose supplement
- The dosage of D-mannose used for UTIs in clinical trials, which is often quite different than suggested dosages on product labels
- The potential side-effects and drug interactions with D-mannose
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Latest Clinical Research Updates for D-Mannose Supplements
D-Mannose for Preventing UTI?
April 12, 2024
Does D-mannose help prevent urinary tract infections? Find out what a recent study showed in the What It Does section of our D-Mannose Supplements Review. Also see our Top Picks for D-Mannose.
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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.
The "Updated" date indicates when new clinical or product information was most recently added. In the full review (available to CL members), the newest information is highlighted in yellow and, if a new product is added, it is footnoted in the results table, showing the date added to the review.
